Peer-to-peer (P2P) clients (programs) are more vulnerable than email clients. IM and file-sharing clients are designed to be left running. They continually broadcast your online presence. That makes your computer -- along with any vulnerabilities -- easy for a hacker or worm to find. Worse yet, many P2P programs install unwanted software themselves.
P2P attachments, like email attachments, can carry viruses, Trojan horses, and worms. A new breed of worms uses the basic structure of IM to propagate. These worms send copies of themselves to the members of your buddy list. The message may contain a link to a Web site that downloads more malicious code, like a Trojan horse.
Instant Messaging is well suited to "social engineering". An attacker can assume virtually identity they want to. You simply do not know who you're dealing with. The highly social nature of IM makes it easy to lull people into a trusting relationship. From there, the imposter can launch scams, identity-theft, and other predatory attacks.
P2P networks are not protected from eavesdropping. They're also vulnerable to "spoofing" -- changing addresses -- so that messages appear to come from a "buddy" when they really come from an attacker. [news] [more news]
A good all-around security system -- like the 7-step Plan -- plus special attention to some safeguards should provide good protection from IM and file-sharing hazards.
Using Instant Messaging and Chat Rooms Safely -- from US Computer Emergency Readiness Team
Instant messaging safety and privacy tips -- from Microsoft
http://www.symantec.com/homecomputing/library/mrim.html
http://www.symantec.com/symadvantage/014/instant.html